Vaping compositions

ABSTRACT

Vaping composition including:
         at least one vaping base composition;   nicotine and/or a nicotine substitute suitable for vaping;   at least one acid suitable for vaping; and   optionally at least one flavouring suitable for vaping,
 
characterized in that the acid is comprised in a certain concentration so that it tastes neutral.

SCOPE OF THE INVENTION

The present invention concerns the domain of vaping compositions.

TECHNOLOGICAL BACKGROUND

More specifically, the invention concerns vaping compositions includingan acid such as salicylic acid, to regulate the tingling in the throatand to enhance the aromatic strength in electronic cigarette liquids.

Electronic cigarettes are also called vape pens or e-cigarettes. Anelectronic cigarette is a device allowing you to at least partiallyvaporise some material, usually a liquid, called vaping or e-liquid, inorder to create an aerosol suitable for inhalation. The vaping liquidcontains in particular nicotine, which, once vaporised and inhaled,reproduces similar or identical sensations to those felt by inhaling thesmoke of a conventional cigarette.

In this regard, the electronic cigarette comprises three main sectionscontained in a plastic and/or metal casing:

-   -   a battery, usually rechargeable,    -   a cartridge or tank containing a liquid called an “e-liquid”,        and    -   a vaporising device (an atomiser).

The vaping composition can be contained in a cartridge (which can besilicone, PET, PMMA or some non-corrodible metal) or a container (whichcan be PMMA/polyethylene, PYREX®, borosilicate glass or somenon-corrodible metal), to which a device may be added for drawing in theliquid through capillary action (in particular in silica, fibreglass,cotton, ceramic metallic fabric, nylon threads, or borosilicate fibre)in contact with the vaporising system. The vaporising device usuallycomprises a thread submersed in the liquid contained in the tank and aheating system allowing for the liquid absorbed by the thread to beheated up in order to vaporise it. An air inlet at the end has beenbuilt in to allow inhalation. Documents WO2004/095955 and WO2015/100361can be cited to illustrate such electronic cigarettes.

While inhaling, the vaporised components inhaled are generally mixedwith droplets of liquid compounds that have not been vaporised. Also,condensation may be produced by the cooling down of vaporised componentsduring inhalation. Thus, the substance actually inhaled is usuallycalled an aerosol, in other words it is formed from liquid particles insuspension in a gas mixture. This offers a real advantage in terms ofconsumer health compared to conventional cigarettes inhaled throughcombustion. In fact, as part of this process, electronic cigarettesallow for the exact amount of inhaled product to be controlled, whichmakes it possible to exclude the use of toxic products such as CMRproducts (which you cannot do with conventional cigarettes).

The vaping liquid, also called “e-liquid” is generally a liquidcontaining a base (such as a mixture of glycerin, preferablyplant-based, propylene glycol, water, etc.) to which flavourings andnicotine are added.

Thus, e-liquids are mainly comprised of the following components:

-   -   synthetic propylene glycol (approximately 65%),    -   glycerin and/or glycerol (approximately 25%)    -   water* (5% to 10%)    -   flavouring(s) and/or colourant(s) (2% to 5%)    -   nicotine (0 mg/ml to 20 mg/ml).        *Water is rarely added, it generally is derived from other        ingredients (flavourings, solvents, etc.).

One of the main objectives of e-cigarettes is to simulate the effects ofconventional cigarettes, which provide pleasure to cigarette smokers,without inducing the negative effects.

It is common knowledge that the pleasurable physiological effects ofconventional cigarettes may be related to nicotine. Nicotine is apsychoactive substance causing a feeling of relaxation, it acts as ananxiolytic, antidepressant, hunger-curbing substance and in some userseven provides intellectual stimulation. However, nicotine is alsoresponsible for causing a tingling sensation in the throat, typicallyknown as “throat-hit” or “hit”, which is linked to its concentrationpresent in cigarette smoke. This tingling is not usually a pleasantsensation for smokers.

However, e-cigarette shave difficulties to reproduce the effects ofnicotine in a controlled manner. The current solution is usually to addbenzoic acid in order to increase the bioavailability of nicotine (themore soluble, protonated form), in this way serving to exacerbate itsphysiological properties. However, such e-liquids always cause tinglingin the throat (“hit”). The Applicant has recently discovered that thebioavailability of nicotine and throat tingling (“hit”) are two effectsdistinct from one another.

Thus, the Applicant was surprised to discover that the nature of theacid used allows for the decorrelation of the sensation of throattingling with other nicotine-induced physiological effects that thesmoker finds pleasurable. Benzoic acid has a metallic taste that seemsto be related to the sensation of tingling in the throat. In fact, byusing salicylic acid which has a neutral taste, the Applicant has notedthe decorrelation of the sensation of throat tingling with othernicotine-induced physiological effects that the smoker findspleasurable. It is in any case important to note that the acid is not acarcinogen, mutagen and/or toxic for reproduction (traditionally knownas “CMR”), nor is it quite simply dangerous for the respiratory tract.It is vital that electronic cigarettes present satisfactory toxicologycharacteristics (nature and amount of ingredients) in order to upholdtheir status as a safe alternative (in terms of public health) comparedto conventional cigarettes. Thus, it is possible to envisage e-liquidswith fixed quantities of nicotine that cause pleasurable physiologicaleffects (a feeling of relaxation, intellectual stimulation, anxiolyticand antidepressant properties, etc.) that are controlled and safe (interms of health), while delivering a separately-controlled effect oftingling in the throat (hit) which is predominant with nicotine. One ofthe main aims of the present invention is thus to offer differentcompositions of e-liquids that allow the user to choose thenicotine-related parameter on which the user can act in smokingcessation.

SUMMARY OF THE INVENTION

The purpose of the present invention therefore concerns a vapingcomposition comprising:

-   -   at least one vaping base composition;    -   nicotine and/or a nicotine substitute suitable for vaping;    -   at least one acid suitable for vaping; and    -   optionally at least one flavouring suitable for vaping,        characterized in that the acid is comprised at a particular        concentration so that it tastes neutral.

The aim of the present invention also relates to the process formanufacturing a composition according to the present invention,comprising the following steps:

a) mixing nicotine in a solvent, such as propylene glycol suitable forvaping, with addition of acid to obtain a nicotine salt solution;b) adding to the vaping base solution the solution obtained in step (a);c) optionally adding at least one flavouring and/or nicotine and/or anicotine substitute to the vaping base solution of step (b) or to thesolution obtained in step (a); andd) recovering of the composition thus obtained in step (c) or (b).

Moreover, the purpose of the present invention concerns the use of acomposition according to the present invention as an electroniccigarette liquid.

In addition, the purpose of the present invention concerns the use of ataste-neutral acid suitable for vaping, such as salicylic acid, toregulate the nicotine-induced tingling in the throat felt by a userduring vaping and/or to enhance the aromatic strength in an electroniccigarette liquid. In fact, beneficially, the purpose of the presentinvention makes it possible to provide vaping compositions in which thenicotine-related tingling in the throat is decorrelated with thenicotine concentration. This allows for the creation of vapingcompositions which are not restrictive for users who do not enjoy thenicotine-related tingling in their throats. Thus, users who aresensitive to tingling in the throat can nonetheless benefit from anicotine intake that produces the other, more desirable effects.

The purpose of the present invention also concerns the use of ataste-neutral acid suitable for vaping, such as salicylic acid, forelectronic cigarette compositions to help with the process of nicotinecessation.

The purpose of the present invention therefore relates to the electroniccigarettes containing a composition according to the present invention.

The purpose of the present invention also concerns the electroniccigarette cartridge containing a composition according to the presentinvention.

Definitions

Within the context of the present invention, products (such as nicotine,acid, solvent, etc.) “suitable for vaping” refers to a product that issufficiently volatile to be vaped, and/or sufficiently soluble in thevaping liquid to be atomised with this liquid during vaping and thatmeets the toxicity criteria and/or that this acid is not a CMR agent ortoxic for the respiratory tract, including the upper respiratory tract(mouth, nose, nasal cavities, pharynx, larynx), the lower respiratorytract (trachea, primary and lumbar bronchi, bronchioles) or exchangeareas (air duct and air sacs, pulmonary alveoli). Specifically, the acidis not a CMR agent. The acid is not toxic to the respiratory tract.

Within the context of the present invention, “nicotine substitute” isunderstood to refer to any product that allows for the obtaining ofnicotine or for the physiological effect of nicotine to be reached. Thiscould for example be a nicotine salt, or a nicotine mixture with anicotine salt.

Within the context of the present invention, the term “acid” is used torefer to at least one component which could have a pKa less than 7, forexample comprised between 1 and 6, and preferably comprised between 2and 5 or even 3 and 4. Beneficially, the pKa of the acid is comprisedbetween 2.5 and 5.5.

Within the context of the present invention, “flavouring” is used torefer to a component or mixture of components that allow for theperception of flavour and possibly odour.

Within the context of the present invention, “neutral taste” is used torefer to no taste and/or odour that is perceived during vaping. Thus,one way to determine whether a product has a neutral taste is to add avaping base, and not to observe any taste difference with the samecomposition in its absence (typically without the use of any otherflavourings). Traditionally, “neutral taste” is recognised by a tasteexpert. For example within the context of this invention, the acid canbe selected from the following list of organic acids:

-   -   formic acid, acetic acid, propionic acid, butyric acid, valeric        acid, caproic acid, caprylic acid, capric acid, citric acid,        lauric acid, myristic acid, palmitic acid, salicylic acid,        stearic acid, oleic acid, linoleic acid, linolenic acid,        phenylacetic acid, pyruvic acid, levulinic acid, tartaric acid,        lactic acid, succinic acid, fumaric acid, feminic acid, gluconic        acid, cacid, malonic acid and malic acid;        at a concentration less than 5% by weight of the composition to        deliver a neutral taste as per its intended meaning according to        the present invention.

Within the context of the present invention, “neutral taste” can be usedto refer to the absence of a perception of taste.

DETAILED DESCRIPTION

The purpose of the present invention therefore concerns a vapingcomposition as described above.

More specifically, the purpose of the present invention concerns avaping composition comprising:

-   -   at least one vaping base composition;    -   nicotine and/or a nicotine substitute suitable for vaping;    -   at least one acid suitable for vaping; and    -   optionally at least one flavouring suitable for vaping,

characterized in that the acid is comprised in a content of less than 5%by weight of the composition, for example comprised between 0.0001% and1% by acid weight per volume of the composition. Preferably, the vapingcomposition according to the invention is characterised in that thevaping composition comprises at least one acid in a content of less thanor equal to 4% by weight, less than or equal to 3% by weight, less thanor equal to 2% by weight, or even less than or equal to 1.5% by weight.Preferably, the vaping composition according to the invention ischaracterized in that the vaping composition comprises at least one acidin a content of greater than or equal to 0.0001% by weight, greater thanor equal to 0.001% by weight, greater than or equal to 0.01% by weight,or even greater than or equal to 0.1% by weight. Preferably, the vapingcomposition according to the invention is characterized in that thevaping composition comprises at least one acid in a content of between0.0001% and 4% by weight, between 0.001% and 3% by weight, between 0.01%and 2% by weight, between 0.1% and 1% by weight, or even preferably lessthan or equal to 0.9% by weight.

Beneficially, the vaping composition according to the invention can becharacterized in that the said composition comprises less than 0.1% byweight of benzoic acid per volume of the composition, preferably thesaid composition is free of benzoic acid. In fact, the present inventiondoes not from the outset exclude the presence of benzoic acid at lowdoses, rather within the limits defined by the health authorities (forexample at a rate less than 0.1%). Within this context, the amount ofbenzoic acid is preferably less than 0.05%, less than 0.01%, preferablyless than 0.001%, or even preferably that benzoic acid is completelyabsent from the composition.

The purpose of the present invention concerns in particular a vapingcomposition as described above, characterized in that the acid is anorganic acid, such as salicylic acid. Preferably, the organic acidcomprises at least one aromatic ring. Preferably, the organic acidcomprises at least one carboxylic acid. Preferably, the organic acidcomprises at least one hydroxyl function. Preferably, the organic acidcomprises at least one aromatic ring, one carboxylic acid, and/or atleast one hydroxyl function. Even more preferably, the organic acidcomprises one aromatic ring on which the carboxylic acid function andthe hydroxyl function are in position 1-2, 1-3, 1-4, 1-5 or 1-6 on thearomatic ring. Within the context of the present invention, “aromaticring” is used to refer to a ring in C5, C6, C7 or C8 comprising anaromaticity. Preferably, the aromatic ring comprises an aromatic ring inC6 (benzene ring).

Specifically, the acid is not a CMR agent. The acid is not toxic to therespiratory tract.

In a particular embodiment, the vaping composition according to theinvention comprises a single acid and is free from any other acid (inparticular benzoic acid).

In a particular embodiment, the vaping composition according to theinvention comprises a combination of two acids and is free of any otheracid (in particular benzoic acid).

In a particular embodiment, the vaping composition according to theinvention comprises a combination of three acids and is free of anyother acid (in particular benzoic acid).

Within the context of the present invention, “one, two or three acids”is used to refer to the fact that the composition may comprise at leastone, two or three acids, or alternatively, that the compositioncomprises exactly one, two or three acids.

For example, the acid can be selected from the following list of organicacids: formic acid, acetic acid, propionic acid, butyric acid, valericacid, caproic acid, caprylic acid, capric acid, citric acid, lauricacid, myristic acid, palmitic acid, salicylic acid, stearic acid, oleicacid, linoleic acid, linolenic acid, phenylacetic acid, pyruvic acid,levulinic acid, tartaric acid, lactic acid, succinic acid, fumaric acid,feminic acid, gluconic acid, sartric acid, malonic acid and malic acid.

The purpose of the present invention further concerns a vapingcomposition as described above, characterized in that the vapingcomposition comprises at least one acid in a content of less than 5% byweight, for example comprised between 0.0001% and 1% by weight of acidper volume of the composition. Preferably, the vaping compositionaccording to the present invention is characterized in that it comprisesat least one acid in a content of less than or equal to 4% by weight,less than or equal to 3% by weight, less than or equal to 2% by weight,or even less than or equal to 1.5% by weight. Preferably, the vapingcomposition according to the invention is characterized in that itcomprises at least one acid in a content of greater than or equal to0.0001% by weight, greater than or equal to 0.001% by weight, greaterthan or equal to 0.01% by weight, or even greater than or equal to 0.1%by weight. Preferably, the vaping composition according to the inventionis characterized in that it comprises at least one acid in a contentcomprised between 0.0001% and 4% by weight, between 0.001% and 3% byweight, between 0.01% and 2% by weight, between 0.1% and 1% by weight,and more preferably less than or equal to 0.9% by weight.

In a particular embodiment, the composition comprises formic acid in acontent of less than 5% by weight of the vaping composition according tothe invention, and preferably comprised between 0.0001% and 4% byweight, between 0.001% and 3% by weight, between 0.01% and 2% by weight,between 0.1% and 1% by weight, or more preferably, less than or equal to0.9% by weight.

In a particular embodiment, the composition comprises acetic acid in acontent of less than 5% by weight of the vaping composition according tothe invention, and preferably comprised between 0.0001% and 4% byweight, between 0.001% and 3% by weight, between 0.01% and 2% by weight,between 0.1% and 1% by weight, or more preferably, less than or equal to0.9% by weight.

In a particular embodiment, the composition comprises propionic acid ina content of less than 5% by weight of the vaping composition accordingto the invention, and preferably comprised between 0.0001% and 4% byweight, between 0.001% and 3% by weight, between 0.01% and 2% by weight,between 0.1% and 1% by weight, or more preferably, less than or equal to0.9% by weight.

In a particular embodiment, the composition comprises butyric acid in acontent of less than 5% by weight of the vaping composition according tothe invention, and preferably comprised between 0.0001% and 4% byweight, between 0.001% and 3% by weight, between 0.01% and 2% by weight,between 0.1% and 1% by weight, or more preferably, less than or equal to0.9% by weight.

In a particular embodiment, the composition comprises valeric acid in acontent of less than 5% by weight of the vaping composition according tothe invention, and preferably comprised between 0.0001% and 4% byweight, between 0.001% and 3% by weight, between 0.01% and 2% by weight,between 0.1% and 1% by weight, or more preferably, less than or equal to0.9% by weight.

In a particular embodiment, the composition comprises caproic acid in acontent of less than 5% by weight of the vaping composition according tothe invention, and preferably comprises between 0.0001% and 4% byweight, between 0.001% and 3% by weight, between 0.01% and 2% by weight,between 0.1% and 1% by weight, or more preferably, less than or equal to0.9% by weight.

In a particular embodiment, the composition comprises caprylic acid in acontent of less than 5% by weight of the vaping composition according tothe invention, and preferably comprised between 0.0001% and 4% byweight, between 0.001% and 3% by weight, between 0.01% and 2% by weight,between 0.1% and 1% by weight, or more preferably, less than or equal to0.9% by weight.

In a particular embodiment, the composition comprises capric acid in acontent of less than 5% by weight of the vaping composition according tothe invention, and preferably comprised between 0.0001% and 4% byweight, between 0.001% and 3% by weight, between 0.01% and 2% by weight,between 0.1% and 1% by weight, or more preferably, less than or equal to0.9% by weight.

In a particular embodiment, the composition comprises citric acid in acontent of less than 5% by weight of the vaping composition according tothe invention, and preferably comprised between 0.0001% and 4% byweight, between 0.001% and 3% by weight, between 0.01% and 2% by weight,between 0.1% and 1% by weight, or more preferably, less than or equal to0.9% by weight.

In a particular embodiment, the composition comprises lauric acid in acontent of less than 5% by weight of the vaping composition according tothe invention, and preferably comprised between 0.0001% and 4% byweight, between 0.001% and 3% by weight, between 0.01% and 2% by weight,between 0.1% and 1% by weight, or more preferably, less than or equal to0.9% by weight.

In a particular embodiment, the composition comprises myristic acid in acontent of less than 5% by weight of the vaping composition according tothe invention, and preferably comprised between 0.0001% and 4% byweight, between 0.001% and 3% by weight, between 0.01% and 2% by weight,between 0.1% and 1% by weight, or more preferably, less than or equal to0.9% by weight.

In a particular embodiment, the composition comprises palmitic acid in acontent of less than 5% by weight of the vaping composition according tothe invention, and preferably comprised between 0.0001% and 4% byweight, between 0.001% and 3% by weight, between 0.01% and 2% by weight,between 0.1% and 1% by weight, or more preferably, less than or equal to0.9% by weight.

In a particular embodiment, the composition comprises salicylic acid ina content of less than 5% by weight of the vaping composition accordingto the invention, and preferably comprised between 0.0001% and 4% byweight, between 0.001% and 3% by weight, between 0.01% and 2% by weight,between 0.1% and 1% by weight, or more preferably, less than or equal to0.9% by weight.

In a particular embodiment, the composition comprises stearic acid in acontent of less than 5% by weight of the vaping composition according tothe invention, and preferably comprised between 0.0001% and 4% byweight, between 0.001% and 3% by weight, between 0.01% and 2% by weight,between 0.1% and 1% by weight, or more preferably, less than or equal to0.9% by weight.

In a particular embodiment, the composition comprises oleic acid in acontent of less than 5% by weight of the vaping composition according tothe invention, and preferably falling between 0.0001% and 4% by weight,between 0.001% and 3% by weight, between 0.01% and 2% by weight, between0.1% and 1% by weight, or more preferably, less than or equal to 0.9% byweight.

In a particular embodiment, the composition comprises linoleic acid in acontent of less than 5% by weight of the vaping composition according tothe invention, and preferably comprised between 0.0001% and 4% byweight, between 0.001% and 3% by weight, between 0.01% and 2% by weight,between 0.1% and 1% by weight, or more preferably, less than or equal to0.9% by weight.

In a particular embodiment, the composition comprises linolenic acid ina content of less than 5% by weight of the vaping composition accordingto the invention, and preferably comprised between 0.0001% and 4% byweight, between 0.001% and 3% by weight, between 0.01% and 2% by weight,between 0.1% and 1% by weight, or more preferably, less than or equal to0.9% by weight.

In a particular embodiment, the composition comprises phenylacetic acidin a content of less than 5% by weight of the vaping compositionaccording to the invention, and preferably comprised between 0.0001% and4% by weight, between 0.001% and 3% by weight, between 0.01% and 2% byweight, between 0.1% and 1% by weight, or more preferably, less than orequal to 0.9% by weight.

In a particular embodiment, the composition comprises pyruvic acid in acontent of less than 5% by weight of the vaping composition according tothe invention, and preferably comprised between 0.0001% and 4% byweight, between 0.001% and 3% by weight, between 0.01% and 2% by weight,between 0.1% and 1% by weight, or more preferably, less than or equal to0.9% by weight.

In a particular embodiment, the composition comprises levulinic acid ina content of less than 5% by weight of the vaping composition accordingto the invention, and preferably comprised between 0.0001% and 4% byweight, between 0.001% and 3% by weight, between 0.01% and 2% by weight,between 0.1% and 1% by weight, or more preferably, less than or equal to0.9% by weight.

In a particular embodiment, the composition comprises tartaric acid in acontent of less than 5% by weight of the vaping composition according tothe invention, and preferably falling between 0.0001% and 4% by weight,between 0.001% and 3% by weight, between 0.01% and 2% by weight, between0.1% and 1% by weight, or more preferably, less than or equal to 0.9% byweight.

In a particular embodiment, the composition comprises lactic acid in acontent of less than 5% by weight of the vaping composition according tothe invention, and preferably comprised between 0.0001% and 4% byweight, between 0.001% and 3% by weight, between 0.01% and 2% by weight,between 0.1% and 1% by weight, or more preferably, less than or equal to0.9% by weight.

In a particular embodiment, the composition comprises succinic acid in acontent of less than 5% by weight of the vaping composition according tothe invention, and preferably comprised between 0.0001% and 4% byweight, between 0.001% and 3% by weight, between 0.01% and 2% by weight,between 0.1% and 1% by weight, or more preferably, less than or equal to0.9% by weight.

In a particular embodiment, the composition comprises fumaric acid in acontent of less than 5% by weight of the vaping composition according tothe invention, and preferably falling between 0.0001% and 4% by weight,between 0.001% and 3% by weight, between 0.01% and 2% by weight, between0.1% and 1% by weight, or more preferably, less than or equal to 0.9% byweight.

In a particular embodiment, the composition comprises feminic acid in acontent of less than 5% by weight of the vaping composition according tothe invention, and preferably comprised between 0.0001% and 4% byweight, between 0.001% and 3% by weight, between 0.01% and 2% by weight,between 0.1% and 1% by weight, or more preferably, less than or equal to0.9% by weight.

In a particular embodiment, the composition comprises gluconic acid in acontent of less than 5% by weight of the vaping composition according tothe invention, and preferably comprised between 0.0001% and 4% byweight, between 0.001% and 3% by weight, between 0.01% and 2% by weight,between 0.1% and 1% by weight, or more preferably, less than or equal to0.9% by weight.

In a particular embodiment, the composition comprises sartric acid in acontent of less than 5% by weight of the vaping composition according tothe invention, and preferably comprised between 0.0001% and 4% byweight, between 0.001% and 3% by weight, between 0.01% and 2% by weight,between 0.1% and 1% by weight, or more preferably, less than or equal to0.9% by weight.

In a particular embodiment, the composition comprises malonic acid in acontent of less than 5% by weight of the vaping composition according tothe invention, and preferably comprised between 0.0001% and 4% byweight, between 0.001% and 3% by weight, between 0.01% and 2% by weight,between 0.1% and 1% by weight, or more preferably, less than or equal to0.9% by weight.

In a particular embodiment, the composition comprises malic acid in acontent of less than 5% by weight of the vaping composition according tothe invention, and preferably comprised between 0.0001% and 4% byweight, between 0.001% and 3% by weight, between 0.01% and 2% by weight,between 0.1% and 1% by weight, or more preferably, less than or equal to0.9% by weight.

The purpose of the present invention further concerns a vapingcomposition as described above, characterized in that the total amountof nicotine equivalent is less than 5% by weight, for example comprisedbetween 0.5% and 3% by weight of nicotine equivalent. Preferably, thevaping composition according to the invention is characterized in thatthe total amount of nicotine equivalent is less than or equal to 4% byweight, less than or equal to 3% by weight, less than or equal to 2% byweight, or even less than or equal to 1.5% by weight. Preferably, thevaping composition according to the invention is characterized in thatthe total amount of nicotine equivalent is greatergreater than or equalto 0.1% by weight, greatergreater than or equal to 0.5% by weight,greatergreater than or equal to 1% by weight, or even greatergreaterthan or equal to 1.5% by weight. Preferably, the vaping compositionaccording to the invention is characterized in that the vapingcomposition comprises at least one acid in a content of comprisedbetween 0.1% and 2.5% by weight, between 0.5% and 2.4% by weight,between 1% and 2.3% by weight, between 1.2% and 2.2% by weight, and morepreferably between 1.5% and 2.1% by weight. It is emphasised that thedensity of the mixture being almost 1, an amount of nicotine equivalentof 2% corresponds to 20 mg/ml.

Within the context of the present invention, “nicotine equivalent” isused to refer to an amount of product having the characteristics of purenicotine at the given amount.

The purpose of the present invention further concerns a vapingcomposition as described above, characterized in that the ratio betweennicotine and acid (nicotine:acid ratio) can be less than or equal to 1:5by mass, less than or equal to 1:4, less than or equal to 1:3, less thanor equal to 1:2, less than or equal to 1:1, less than or equal to 1:0.9,less than or equal to 1:0.8, less than or equal to 1:0.7, less than orequal to 1:0.6, less than or equal to 1:0.5, less than or equal to1:0.4, less than or equal to 1:0.3, less than or equal to 1:0.2 or evenless than or equal to 1:0.1 by weight.

Preferably, the purpose of the present invention concerns a vapingcomposition as described above, characterized in that the nicotine:acidratio can be less than or equal to 1:5 by mass, less than or equal to1:4, less than or equal to 1:3, less than or equal to 1:2, less than orequal to 1:1, less than or equal to 1:0.9, less than or equal to 1:0.8,less than or equal to 1:0.7, less than or equal to 1:0.6, less than orequal to 1:0.5, less than or equal to 1:0.4, less than or equal to1:0.3, less than or equal to 1:0.2 or even less than or equal to 1:0.1by weight, and in which the acid can be selected from the following listof organic acids: formic acid, acetic acid, propionic acid, butyricacid, valeric acid, caproic acid, caprylic acid, capric acid, citricacid, lauric acid, myristic acid, palmitic acid, salicylic acid, stearicacid, oleic acid, linoleic acid, linolenic acid, phenylacetic acid,pyruvic acid, levulinic acid, tartaric acid, lactic acid, succinic acid,fumaric acid, feminic acid, gluconic acid, sartric acid, malonic acidand malic acid.

In a particular embodiment, the purpose of the present inventionconcerns a vaping composition as described above in which the acid isformic acid in a content of less than 5% by weight of the vapingcomposition according to the invention, and preferably comprised between0.0001% and 4% by weight, between 0.001% and 3% by weight, between 0.01%and 2% by weight, between 0.1% and 1% by weight, or more preferably,less than or equal to 0.9% by weight, and characterized in that thenicotine:acid ratio can be less than or equal to 1:5 by mass, less thanor equal to 1:4, less than or equal to 1:3, less than or equal to 1:2,less than or equal to 1:1, less than or equal to 1:0.9, less than orequal to 1:0.8, less than or equal to 1:0.7, less than or equal to1:0.6, less than or equal to 1:0.5, less than or equal to 1:0.4, lessthan or equal to 1:0.3, less than or equal to 1:0.2 or even less than orequal to 1:0.1 by weight.

In a particular embodiment, the purpose of the present inventionconcerns a vaping composition as described above in which the acid isacetic acid in a content of less than 5% by weight of the vapingcomposition according to the invention, and preferably comprised between0.0001% and 4% by weight, between 0.001% and 3% by weight, between 0.01%and 2% by weight, between 0.1% and 1% by weight, or more preferably,less than or equal to 0.9% by weight, and characterized in that thenicotine:acid ratio can be less than or equal to 1:5 by mass, less thanor equal to 1:4, less than or equal to 1:3, less than or equal to 1:2,less than or equal to 1:1, less than or equal to 1:0.9, less than orequal to 1:0.8, less than or equal to 1:0.7, less than or equal to1:0.6, less than or equal to 1:0.5, less than or equal to 1:0.4, lessthan or equal to 1:0.3, less than or equal to 1:0.2 or even less than orequal to 1:0.1 by weight.

In a particular embodiment, the purpose of the present inventionconcerns a vaping composition as described above in which the acid ispropionic acid in a content of less than 5% by weight of the vapingcomposition according to the invention, and preferably comprised between0.0001% and 4% by weight, between 0.001% and 3% by weight, between 0.01%and 2% by weight, between 0.1% and 1% by weight, or more preferably,less than or equal to 0.9% by weight, and characterized in that thenicotine:acid ratio can be less than or equal to 1:5 by mass, less thanor equal to 1:4, less than or equal to 1:3, less than or equal to 1:2,less than or equal to 1:1, less than or equal to 1:0.9, less than orequal to 1:0.8, less than or equal to 1:0.7, less than or equal to1:0.6, less than or equal to 1:0.5, less than or equal to 1:0.4, lessthan or equal to 1:0.3, less than or equal to 1:0.2 or even less than orequal to 1:0.1 by weight.

In a particular embodiment, the purpose of the present inventionconcerns a vaping composition as described above in which the acid isbutyric acid in a content of less than 5% by weight of the vapingcomposition according to the invention, and preferably comprised between0.0001% and 4% by weight, between 0.001% and 3% by weight, between 0.01%and 2% by weight, between 0.1% and 1% by weight, or more preferably,less than or equal to 0.9% by weight, and characterized in that thenicotine:acid ratio can be less than or equal to 1:5 by mass, less thanor equal to 1:4, less than or equal to 1:3, less than or equal to 1:2,less than or equal to 1:1, less than or equal to 1:0.9, less than orequal to 1:0.8, less than or equal to 1:0.7, less than or equal to1:0.6, less than or equal to 1:0.5, less than or equal to 1:0.4, lessthan or equal to 1:0.3, less than or equal to 1:0.2 or even less than orequal to 1:0.1 by weight.

In a particular embodiment, the purpose of the present inventionconcerns a vaping composition as described above in which the acid isvaleric acid in a content of less than 5% by weight of the vapingcomposition according to the invention, and preferably comprised between0.0001% and 4% by weight, between 0.001% and 3% by weight, between 0.01%and 2% by weight, between 0.1% and 1% by weight, or more preferably,less than or equal to 0.9% by weight, and characterized in that thenicotine:acid ratio less can be than or equal to 1:5 by mass, less thanor equal to 1:4, less than or equal to 1:3, less than or equal to 1:2,less than or equal to 1:1, less than or equal to 1:0.9, less than orequal to 1:0.8, less than or equal to 1:0.7, less than or equal to1:0.6, less than or equal to 1:0.5, less than or equal to 1:0.4, lessthan or equal to 1:0.3, less than or equal to 1:0.2 or even less than orequal to 1:0.1 by weight.

In a particular embodiment, the purpose of the present inventionconcerns a vaping composition as described above in which the acid iscaproic acid in a content of less than 5% by weight of the vapingcomposition according to the invention, and preferably comprised between0.0001% and 4% by weight, between 0.001% and 3% by weight, between 0.01%and 2% by weight, between 0.1% and 1% by weight, or more preferably,less than or equal to 0.9% by weight, and characterized in that thenicotine:acid ratio can be less than or equal to 1:5 by mass, less thanor equal to 1:4, less than or equal to 1:3, less than or equal to 1:2,less than or equal to 1:1, less than or equal to 1:0.9, less than orequal to 1:0.8, less than or equal to 1:0.7, less than or equal to1:0.6, less than or equal to 1:0.5, less than or equal to 1:0.4, lessthan or equal to 1:0.3, less than or equal to 1:0.2 or even less than orequal to 1:0.1 by weight.

In a particular embodiment, the purpose of the present inventionconcerns a vaping composition as described above in which the acid iscaprylic acid in a content of less than 5% by weight of the vapingcomposition according to the invention, and preferably comprised between0.0001% and 4% by weight, between 0.001% and 3% by weight, between 0.01%and 2% by weight, between 0.1% and 1% by weight, or more preferably,less than or equal to 0.9% by weight, and characterized in that thenicotine:acid ratio can be less than or equal to 1:5 by mass, less thanor equal to 1:4, less than or equal to 1:3, less than or equal to 1:2,less than or equal to 1:1, less than or equal to 1:0.9, less than orequal to 1:0.8, less than or equal to 1:0.7, less than or equal to1:0.6, less than or equal to 1:0.5, less than or equal to 1:0.4, lessthan or equal to 1:0.3, less than or equal to 1:0.2 or even less than orequal to 1:0.1 by weight.

In a particular embodiment, the purpose of the present inventionconcerns a vaping composition as described above in which the acid iscapric acid in a content of less than 5% by weight of the vapingcomposition according to the invention, and preferably comprised between0.0001% and 4% by weight, between 0.001% and 3% by weight, between 0.01%and 2% by weight, between 0.1% and 1% by weight, or more preferably,less than or equal to 0.9% by weight, and characterized in that thenicotine:acid ratio can be less than or equal to 1:5 by mass, less thanor equal to 1:4, less than or equal to 1:3, less than or equal to 1:2,less than or equal to 1:1, less than or equal to 1:0.9, less than orequal to 1:0.8, less than or equal to 1:0.7, less than or equal to1:0.6, less than or equal to 1:0.5, less than or equal to 1:0.4, lessthan or equal to 1:0.3, less than or equal to 1:0.2 or even less than orequal to 1:0.1 by weight.

In a particular embodiment, the purpose of the present inventionconcerns a vaping composition as described above in which the acid iscitric acid in a content of less than 5% by weight of the vapingcomposition according to the invention, and preferably comprised between0.0001% and 4% by weight, between 0.001% and 3% by weight, between 0.01%and 2% by weight, between 0.1% and 1% by weight, or more preferably,less than or equal to 0.9% by weight, and characterized in that thenicotine:acid ratio can be less than or equal to 1:5 by mass, less thanor equal to 1:4, less than or equal to 1:3, less than or equal to 1:2,less than or equal to 1:1, less than or equal to 1:0.9, less than orequal to 1:0.8, less than or equal to 1:0.7, less than or equal to1:0.6, less than or equal to 1:0.5, less than or equal to 1:0.4, lessthan or equal to 1:0.3, less than or equal to 1:0.2 or even less than orequal to 1:0.1 by weight.

In a particular embodiment, the purpose of the present inventionconcerns a vaping composition as described above in which the acid islauric acid in a content of less than 5% by weight of the vapingcomposition according to the invention, and preferably comprised between0.0001% and 4% by weight, between 0.001% and 3% by weight, between 0.01%and 2% by weight, between 0.1% and 1% by weight, or more preferably,less than or equal to 0.9% by weight, and characterized in that thenicotine:acid ratio can be less than or equal to 1:5 by mass, less thanor equal to 1:4, less than or equal to 1:3, less than or equal to 1:2,less than or equal to 1:1, less than or equal to 1:0.9, less than orequal to 1:0.8, less than or equal to 1:0.7, less than or equal to1:0.6, less than or equal to 1:0.5, less than or equal to 1:0.4, lessthan or equal to 1:0.3, less than or equal to 1:0.2 or even less than orequal to 1:0.1 by weight.

In a particular embodiment, the purpose of the present inventionconcerns a vaping composition as described above in which the acid ismyristic acid in a content of less than 5% by weight of the vapingcomposition according to the invention, and preferably comprised between0.0001% and 4% by weight, between 0.001% and 3% by weight, between 0.01%and 2% by weight, between 0.1% and 1% by weight, or more preferably,less than or equal to 0.9% by weight, and characterized in that thenicotine:acid ratio can be less than or equal to 1:5 by mass, less thanor equal to 1:4, less than or equal to 1:3, less than or equal to 1:2,less than or equal to 1:1, less than or equal to 1:0.9, less than orequal to 1:0.8, less than or equal to 1:0.7, less than or equal to1:0.6, less than or equal to 1:0.5, less than or equal to 1:0.4, lessthan or equal to 1:0.3, less than or equal to 1:0.2 or even less than orequal to 1:0.1 by weight.

In a particular embodiment, the purpose of the present inventionconcerns a vaping composition as described above in which the acid ispalmitic acid in a content of less than 5% by weight of the vapingcomposition according to the invention, and preferably comprised between0.0001% and 4% by weight, between 0.001% and 3% by weight, between 0.01%and 2% by weight, between 0.1% and 1% by weight, or more preferably,less than or equal to 0.9% by weight, and characterized in that thenicotine:acid ratio can be less than or equal to 1:5 by mass, less thanor equal to 1:4, less than or equal to 1:3, less than or equal to 1:2,less than or equal to 1:1, less than or equal to 1:0.9, less than orequal to 1:0.8, less than or equal to 1:0.7, less than or equal to1:0.6, less than or equal to 1:0.5, less than or equal to 1:0.4, lessthan or equal to 1:0.3, less than or equal to 1:0.2 or even less than orequal to 1:0.1 by weight.

In a particular embodiment, the purpose of the present inventionconcerns a vaping composition as described above in which the acid issalicylic acid in a content of less than 5% by weight of the vapingcomposition according to the invention, and preferably comprised between0.0001% and 4% by weight, between 0.001% and 3% by weight, between 0.01%and 2% by weight, between 0.1% and 1% by weight, or more preferably,less than or equal to 0.9% by weight, and characterized in that thenicotine:acid ratio can be less than or equal to 1:5 by mass, less thanor equal to 1:4, less than or equal to 1:3, less than or equal to 1:2,less than or equal to 1:1, less than or equal to 1:0.9, less than orequal to 1:0.8, less than or equal to 1:0.7, less than or equal to1:0.6, less than or equal to 1:0.5, less than or equal to 1:0.4, lessthan or equal to 1:0.3, less than or equal to 1:0.2 or even less than orequal to 1:0.1 by weight.

In a particular embodiment, the purpose of the present inventionconcerns a vaping composition as described above in which the acid isstearic acid in a content of less than 5% by weight of the vapingcomposition according to the invention, and preferably comprised between0.0001% and 4% by weight, between 0.001% and 3% by weight, between 0.01%and 2% by weight, between 0.1% and 1% by weight, or more preferably,less than or equal to 0.9% by weight, and characterized in that thenicotine:acid ratio can be less than or equal to 1:5 by mass, less thanor equal to 1:4, less than or equal to 1:3, less than or equal to 1:2,less than or equal to 1:1, less than or equal to 1:0.9, less than orequal to 1:0.8, less than or equal to 1:0.7, less than or equal to1:0.6, less than or equal to 1:0.5, less than or equal to 1:0.4, lessthan or equal to 1:0.3, less than or equal to 1:0.2 or even less than orequal to 1:0.1 by weight.

In a particular embodiment, the purpose of the present inventionconcerns a vaping composition as described above in which the acid isoleic acid in a content of less than 5% by weight of the vapingcomposition according to the invention, and preferably comprised between0.0001% and 4% by weight, between 0.001% and 3% by weight, between 0.01%and 2% by weight, between 0.1% and 1% by weight, or more preferably,less than or equal to 0.9% by weight, and characterized in that thenicotine:acid ratio can be less than or equal to 1:5 by mass, less thanor equal to 1:4, less than or equal to 1:3, less than or equal to 1:2,less than or equal to 1:1, less than or equal to 1:0.9, less than orequal to 1:0.8, less than or equal to 1:0.7, less than or equal to1:0.6, less than or equal to 1:0.5, less than or equal to 1:0.4, lessthan or equal to 1:0.3, less than or equal to 1:0.2 or even less than orequal to 1:0.1 by weight.

In a particular embodiment, the purpose of the present inventionconcerns a vaping composition as described above in which the acid islinoleic acid in a content of less than 5% by weight of the vapingcomposition according to the invention, and preferably comprised between0.0001% and 4% by weight, between 0.001% and 3% by weight, between 0.01%and 2% by weight, between 0.1% and 1% by weight, or more preferably,less than or equal to 0.9% by weight, and characterized in that thenicotine:acid ratio can be less than or equal to 1:5 by mass, less thanor equal to 1:4, less than or equal to 1:3, less than or equal to 1:2,less than or equal to 1:1, less than or equal to 1:0.9, less than orequal to 1:0.8, less than or equal to 1:0.7, less than or equal to1:0.6, less than or equal to 1:0.5, less than or equal to 1:0.4, lessthan or equal to 1:0.3, less than or equal to 1:0.2 or even less than orequal to 1:0.1 by weight.

In a particular embodiment, the purpose of the present inventionconcerns a vaping composition as described above in which the acid islinolenic acid in a content of less than 5% by weight of the vapingcomposition according to the invention, and preferably comprised between0.0001% and 4% by weight, between 0.001% and 3% by weight, between 0.01%and 2% by weight, between 0.1% and 1% by weight, or more preferably,less than or equal to 0.9% by weight, and characterized in that thenicotine:acid ratio can be less than or equal to 1:5 by mass, less thanor equal to 1:4, less than or equal to 1:3, less than or equal to 1:2,less than or equal to 1:1, less than or equal to 1:0.9, less than orequal to 1:0.8, less than or equal to 1:0.7, less than or equal to1:0.6, less than or equal to 1:0.5, less than or equal to 1:0.4, lessthan or equal to 1:0.3, less than or equal to 1:0.2 or even less than orequal to 1:0.1 by weight.

In a particular embodiment, the purpose of the present inventionconcerns a vaping composition as described above in which the acid isphenylacetic acid in a content of less than 5% by weight of the vapingcomposition according to the invention, and preferably comprised between0.0001% and 4% by weight, between 0.001% and 3% by weight, between 0.01%and 2% by weight, between 0.1% and 1% by weight, or more preferably,less than or equal to 0.9% by weight, and characterized in that thenicotine:acid ratio can be less than or equal to 1:5 by mass, less thanor equal to 1:4, less than or equal to 1:3, less than or equal to 1:2,less than or equal to 1:1, less than or equal to 1:0.9, less than orequal to 1:0.8, less than or equal to 1:0.7, less than or equal to1:0.6, less than or equal to 1:0.5, less than or equal to 1:0.4, lessthan or equal to 1:0.3, less than or equal to 1:0.2 or even less than orequal to 1:0.1 by weight.

In a particular embodiment, the purpose of the present inventionconcerns a vaping composition as described above in which the acid ispyruvic acid in a content of less than 5% by weight of the vapingcomposition according to the invention, and preferably comprised between0.0001% and 4% by weight, between 0.001% and 3% by weight, between 0.01%and 2% by weight, between 0.1% and 1% by weight, or more preferably,less than or equal to 0.9% by weight, and characterized in that thenicotine:acid ratio can be less than or equal to 1:5 by mass, less thanor equal to 1:4, less than or equal to 1:3, less than or equal to 1:2,less than or equal to 1:1, less than or equal to 1:0.9, less than orequal to 1:0.8, less than or equal to 1:0.7, less than or equal to1:0.6, less than or equal to 1:0.5, less than or equal to 1:0.4, lessthan or equal to 1:0.3, less than or equal to 1:0.2 or even less than orequal to 1:0.1 by weight.

In a particular embodiment, the purpose of the present inventionconcerns a vaping composition as described above in which the acid islevulinic acid in a content of less than 5% by weight of the vapingcomposition according to the invention, and preferably comprised between0.0001% and 4% by weight, between 0.001% and 3% by weight, between 0.01%and 2% by weight, between 0.1% and 1% by weight, or more preferably,less than or equal to 0.9% by weight, and characterized in that thenicotine:acid ratio can be less than or equal to 1:5 by mass, less thanor equal to 1:4, less than or equal to 1:3, less than or equal to 1:2,less than or equal to 1:1, less than or equal to 1:0.9, less than orequal to 1:0.8, less than or equal to 1:0.7, less than or equal to1:0.6, less than or equal to 1:0.5, less than or equal to 1:0.4, lessthan or equal to 1:0.3, less than or equal to 1:0.2 or even less than orequal to 1:0.1 by weight.

In a particular embodiment, the purpose of the present inventionconcerns a vaping composition as described above in which the acid istartaric acid in a content of less than 5% by weight of the vapingcomposition according to the invention, and preferably comprised between0.0001% and 4% by weight, between 0.001% and 3% by weight, between 0.01%and 2% by weight, between 0.1% and 1% by weight, or more preferably,less than or equal to 0.9% by weight, and characterized in that thenicotine:acid ratio can be less than or equal to 1:5 by mass, less thanor equal to 1:4, less than or equal to 1:3, less than or equal to 1:2,less than or equal to 1:1, less than or equal to 1:0.9, less than orequal to 1:0.8, less than or equal to 1:0.7, less than or equal to1:0.6, less than or equal to 1:0.5, less than or equal to 1:0.4, lessthan or equal to 1:0.3, less than or equal to 1:0.2 or even less than orequal to 1:0.1 by weight.

In a particular embodiment, the purpose of the present inventionconcerns a vaping composition as described above in which the acid islactic acid in a content of less than 5% by weight of the vapingcomposition according to the invention, and preferably comprised between0.0001% and 4% by weight, between 0.001% and 3% by weight, between 0.01%and 2% by weight, between 0.1% and 1% by weight, or more preferably,less than or equal to 0.9% by weight, and characterized in that thenicotine:acid ratio can be less than or equal to 1:5 by mass, less thanor equal to 1:4, less than or equal to 1:3, less than or equal to 1:2,less than or equal to 1:1, less than or equal to 1:0.9, less than orequal to 1:0.8, less than or equal to 1:0.7, less than or equal to1:0.6, less than or equal to 1:0.5, less than or equal to 1:0.4, lessthan or equal to 1:0.3, less than or equal to 1:0.2 or even less than orequal to 1:0.1 by weight.

In a particular embodiment, the purpose of the present inventionconcerns a vaping composition as described above in which the acid issuccinic acid in a content of less than 5% by weight of the vapingcomposition according to the invention, and preferably comprised between0.0001% and 4% by weight, between 0.001% and 3% by weight, between 0.01%and 2% by weight, between 0.1% and 1% by weight, or more preferably,less than or equal to 0.9% by weight, and characterized in that thenicotine:acid ratio can be less than or equal to 1:5 by mass, less thanor equal to 1:4, less than or equal to 1:3, less than or equal to 1:2,less than or equal to 1:1, less than or equal to 1:0.9, less than orequal to 1:0.8, less than or equal to 1:0.7, less than or equal to1:0.6, less than or equal to 1:0.5, less than or equal to 1:0.4, lessthan or equal to 1:0.3, less than or equal to 1:0.2 or even less than orequal to 1:0.1 by weight.

In a particular embodiment, the purpose of the present inventionconcerns a vaping composition as described above in which the acid isfumaric acid in a content of less than 5% by weight of the vapingcomposition according to the invention, and preferably comprised between0.0001% and 4% by weight, between 0.001% and 3% by weight, between 0.01%and 2% by weight, between 0.1% and 1% by weight, or more preferably,less than or equal to 0.9% by weight, and characterized in that thenicotine:acid ratio can be less than or equal to 1:5 by mass, less thanor equal to 1:4, less than or equal to 1:3, less than or equal to 1:2,less than or equal to 1:1, less than or equal to 1:0.9, less than orequal to 1:0.8, less than or equal to 1:0.7, less than or equal to1:0.6, less than or equal to 1:0.5, less than or equal to 1:0.4, lessthan or equal to 1:0.3, less than or equal to 1:0.2 or even less than orequal to 1:0.1 by weight.

In a particular embodiment, the purpose of the present inventionconcerns a vaping composition as described above in which the acid isfemnic acid in a content of less than 5% by weight of the vapingcomposition according to the invention, and preferably comprised between0.0001% and 4% by weight, between 0.001% and 3% by weight, between 0.01%and 2% by weight, between 0.1% and 1% by weight, or more preferably,less than or equal to 0.9% by weight, and characterized in that thenicotine:acid ratio can be less than or equal to 1:5 by mass, less thanor equal to 1:4, less than or equal to 1:3, less than or equal to 1:2,less than or equal to 1:1, less than or equal to 1:0.9, less than orequal to 1:0.8, less than or equal to 1:0.7, less than or equal to1:0.6, less than or equal to 1:0.5, less than or equal to 1:0.4, lessthan or equal to 1:0.3, less than or equal to 1:0.2 or even less than orequal to 1:0.1 by weight.

In a particular embodiment, the purpose of the present inventionconcerns a vaping composition as described above in which the acid isgluconic acid in a content of less than 5% by weight of the vapingcomposition according to the invention, and preferably comprised between0.0001% and 4% by weight, between 0.001% and 3% by weight, between 0.01%and 2% by weight, between 0.1% and 1% by weight, or more preferably,less than or equal to 0.9% by weight, and characterized in that thenicotine:acid ratio can be less than or equal to 1:5 by mass, less thanor equal to 1:4, less than or equal to 1:3, less than or equal to 1:2,less than or equal to 1:1, less than or equal to 1:0.9, less than orequal to 1:0.8, less than or equal to 1:0.7, less than or equal to1:0.6, less than or equal to 1:0.5, less than or equal to 1:0.4, lessthan or equal to 1:0.3, less than or equal to 1:0.2 or even less than orequal to 1:0.1 by weight.

In a particular embodiment, the purpose of the present inventionconcerns a vaping composition as described above in which the acid issartric acid in a content of less than 5% by weight of the vapingcomposition according to the invention, and preferably comprised between0.0001% and 4% by weight, between 0.001% and 3% by weight, between 0.01%and 2% by weight, between 0.1% and 1% by weight, or more preferably,less than or equal to 0.9% by weight, and characterized in that thenicotine:acid ratio can be less than or equal to 1:5 by mass, less thanor equal to 1:4, less than or equal to 1:3, less than or equal to 1:2,less than or equal to 1:1, less than or equal to 1:0.9, less than orequal to 1:0.8, less than or equal to 1:0.7, less than or equal to1:0.6, less than or equal to 1:0.5, less than or equal to 1:0.4, lessthan or equal to 1:0.3, less than or equal to 1:0.2 or even less than orequal to 1:0.1 by weight.

In a particular embodiment, the purpose of the present inventionconcerns a vaping composition as described above in which the acid ismalonic acid in a content of less than 5% by weight of the vapingcomposition according to the invention, and preferably comprised between0.0001% and 4% by weight, between 0.001% and 3% by weight, between 0.01%and 2% by weight, between 0.1% and 1% by weight, or more preferably,less than or equal to 0.9% by weight, and characterized in that thenicotine:acid ratio can be less than or equal to 1:5 by mass, less thanor equal to 1:4, less than or equal to 1:3, less than or equal to 1:2,less than or equal to 1:1, less than or equal to 1:0.9, less than orequal to 1:0.8, less than or equal to 1:0.7, less than or equal to1:0.6, less than or equal to 1:0.5, less than or equal to 1:0.4, lessthan or equal to 1:0.3, less than or equal to 1:0.2 or even less than orequal to 1:0.1 by weight.

In a particular embodiment, the purpose of the present inventionconcerns a vaping composition as described above in which the acid ismalic acid in a content of less than 5% by weight of the vapingcomposition according to the invention, and preferably comprised between0.0001% and 4% by weight, between 0.001% and 3% by weight, between 0.01%and 2% by weight, between 0.1% and 1% by weight, or more preferably,less than or equal to 0.9% by weight, and characterized in that thenicotine:acid ratio can be less than or equal to 1:5 by mass, less thanor equal to 1:4, less than or equal to 1:3, less than or equal to 1:2,less than or equal to 1:1, less than or equal to 1:0.9, less than orequal to 1:0.8, less than or equal to 1:0.7, less than or equal to1:0.6, less than or equal to 1:0.5, less than or equal to 1:0.4, lessthan or equal to 1:0.3, less than or equal to 1:0.2 or even less than orequal to 1:0.1 by weight.

The purpose of the present invention further concerns a vapingcomposition as described above, characterized in that the vaping basecomposition comprises propylene glycol, glycerol, water, and/or1,3-propanediol.

For example, the vaping composition according to the present inventionmay comprise propylene glycol at a rate greater than or equal to 10% byweight, greater than or equal to 15%, greater than or equal to 20%,greater than or equal to 25%, or even greater than or equal to 30% byweight. Preferably, the vaping composition according to the presentinvention may be characterized in that it comprises propylene glycol ata rate comprised between 1% and 45% by weight, between 5% and 40% byweight, between 10% and 35% by weight, and more preferably between 20%and 30% by weight.

For example, the vaping composition according to the present inventionmay comprise glycerol at a rate greater than or equal to 10% by weight,greater than or equal to 30%, greater than or equal to 40%, greater thanor equal to 45%, or even greater than or equal to 50% by weight.Preferably, the vaping composition according to the present inventionmay be characterized in that it comprises glycerol at a rate between 5%and 80% by weight, between 15% and 70% by weight, between 35% and 65% byweight, and more preferably between 45% and 55% by weight.

For example, the vaping composition according to the present inventionmay comprise water at a rate less than or equal to 10% by weight, lessthan or equal to 5%, less than or equal to 4%, less than or equal to 2%,or even less than or equal to 1% by weight. Preferably, the vapingcomposition according to the present invention may be characterized inthat it comprises water at a rate between 0% and 10% by weight, between1% and 9% by weight, between 2% and 8% by weight, between 3% and % byweight, and more preferably between 4% and 6% by weight, such as 5% byweight.

The purpose of the present invention further concerns a vapingcomposition as described above, characterized in that the vapingcomposition comprises a vaping base composition in a content of greaterthan 10% by weight of the composition for example within a rangecomprises between 50% and 99% by composition weight. For example, thevaping composition according to the present invention may comprise avaping base composition at a rate greater than or equal to 40%, greaterthan or equal to 60% by weight, greater than or equal to 65%, greaterthan or equal to 70%, greater than or equal to 75%, greater than orequal to 80%, greater than or equal to 85%, greater e than or equal to90%, or even greater than or equal to 95% by weight. Preferably, thevaping composition according to the present invention may becharacterized in that the vaping composition comprises a vaping basecomposition at a rate between 50% and 99% by weight, between 60% and 98%by weight, between 65% and 95% by weight, between 70% and 90% by weight,or even between 75% and 85% by weight.

The purpose of the present invention further concerns a vapingcomposition as described above, characterized in that the flavouringcorresponds to a flavouring of plant extract such as mint, a foodflavouring, such as a custard dessert and/or a cigarette flavouring.

The purpose of the present invention therefore also concerns themanufacturing process as described above. Thus the present inventionconcerns the product obtainable by this process.

Moreover, in this process at step (a) which relates to a mixture ofnicotine in a solvent, such as propylene glycol, with the addition of anacid to obtain a nicotine salt solution, can make it possible to obtaina nicotine salt solution that can be used in that form to formulateseveral types of vaping compositions according to the present invention.Thus, the present invention concerns the intermediary product of step(a) obtainable by this step of the process. This intermediary productcan therefore comprise an acid such as that described above and nicotineor a nicotine equivalent as described above.

The purpose of the invention can also comprise derived products whichconcern the cartridge comprising the composition according to theinvention, the electronic cigarette comprising the composition accordingto the invention, etc.

The present invention also allows for the use of a new type of packagingwhere the tingling of the throat can be regulated independently to theflavourings and/or nicotine rate.

EXAMPLES

Several compositions with different flavourings have been formulated andtested. Some of these compositions have been compiled in Table 1 below:

TABLE 1 Composition 1 2 3 4 PG 26.83% 24.91% 27.13% 19.55% GL 54.59%54.41% 54.53% 49.35% Nicotine-salt 3.45% 5.70% 3.05% 7.03% solution Purenicotine 1.67% 1.44% 1.71% 1.32% Flavouring* BG: 13.56% AZ: 13.54% ES:13.58% FR: 22.75% Strength of Very strong Strong Very strong Medium the“Hit” PG: Propylene Glycol GL: Glycerol Nicotine-salt solution: (PG82.05%; Nicotine 9.77%; Salicylic acid 8.18%) BG: “Blond AG ®” comprisesPG 6%; Ethanol 94% AZ: “Absolute Zero ®” comprises Menthol: 1 measure byweight; Laevo-Carvone: 3 measures by weight; D-Limonene: 5 measures byweight. ES: “Empire State ®” comprises4-hydroxy-2,5-dimethyl-3(2H)-furanone FR: Red berry flavouring Thepercentages expressed here are by weight/weight. *The flavourings usedare commercial products whose exact composition is unknown. PG:Propylene Glycol GL: Glycerol Nicotine-salt solution: (PG 82.05%;Nicotine 9.77%; Salicylic acid 8.18%) BG: “Blond AG ®” comprises PG 6%;Ethanol 94% AZ: “Absolute Zero ®” comprises Menthol: 1 measure byweight; Laevo-Carvone: 3 measures by weight; D-Limonene: 5 measures byweight. ES: “Empire State ®” comprises4-hydroxy-2,5-dimethyl-3(2H)-furanone FR: Red berry flavouring Thepercentages expressed here are by weight/weight. *The flavourings usedare commercial products whose exact composition is unknown.These compositions all contain a rate near to 20 mg of nicotine per mlof vaping composition (which is currently the maximum permitted dose inFrance). These compositions are remarkable compared to compositionsusing only benzoic acid as the acid, in that the nicotine-relatedtingling (the “Hit”) is greatly reduced in all of these compositions,which allows for better perception of the flavourings and a betterdelivery of the pleasurable effects of nicotine.

1. A vaping composition comprising: at least one vaping basecomposition; nicotine and/or a nicotine substitute suitable for vaping;at least one acid suitable for vaping; and optionally at least oneflavouring suitable for vaping, characterized in that the acid iscomprised at a certain concentration so that it tastes neutral.
 2. Thevaping composition according to claim 1, characterized in that the acidis an organic acid.
 3. The vaping composition according to claim 1,characterized in that the acid is selected among the list consisting offormic acid, acetic acid, propionic acid, butyric acid, valeric acid,caproic acid, caprylic acid, capric acid, citric acid, lauric acid,myristic acid, palmitic acid, salicylic acid, stearic acid, oleic acid,linoleic acid, linolenic acid, phenylacetic acid, pyruvic acid,levulinic acid, tartaric acid, lactic acid, succinic acid, fumaric acid,feminic acid, gluconic acid, gluconic acid, sartric acid, malonic acidand malic acid, preferably salicylic acid.
 4. The vaping compositionaccording to claim 1, characterized in that the vaping compositioncomprises said at least one acid in a content of less than 5% by weight,for example comprised between 0.0001% and 1% by weight of acid pervolume of the composition.
 5. The vaping composition according to claim1, characterized in that the total amount of nicotine equivalent is lessthan 5% by weight, for example comprised between 0.5% and 3% by weightof nicotine equivalent.
 6. The vaping composition according to claim 1,characterized in that the vaping base composition comprises propyleneglycol, glycerol, water, and/or 1,3-propanediol.
 7. The vapingcomposition according to claim 1, characterized in that the vapingcomposition comprises a vaping base composition in a content greaterthan 10% by weight of the composition, for example within a range of 50%to 99% by weight of the composition.
 8. The vaping composition accordingto claim 1, characterized in that the flavouring corresponds to aflavouring of plant extract, such as mint, a food flavouring, such as acustard dessert and/or a cigarette flavouring.
 9. A process formanufacturing the composition according to claim 1, comprising thefollowing steps: a) mixing nicotine in a solvent, such as propyleneglycol suitable for vaping, with addition of acid to obtain a nicotinesalt solution; b) adding to the vaping base solution the solutionobtained in step (a); c) optionally adding at least one flavouringand/or nicotine and/or a nicotine substitute to the vaping base solutionof step (b) or to the solution obtained in step (a); and d) recoveringof the composition thus obtained in step (c) or (b).
 10. Use of thecomposition according to claim 1, as an electronic cigarette liquid. 11.Use of a taste-suitable neutral acid suitable for vaping to modulate thetingling in the throat due to nicotine felt by a user during vapingand/or for enhancing the aromatic strength in an electronic cigaretteliquid.
 12. Use of a taste-suitable neutral acid suitable for vaping,such as salicylic acid, for an electronic cigarette composition toprovide assistance in smoking cessation.
 13. An electronic cigarettecomprising a composition according to claim
 1. 14. An electroniccigarette cartridge comprising a composition according to claim 1.